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KMID : 0358920220490030300
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Journal of the Korean Academy of Pedodontics
2022 Volume.49 No. 3 p.300 ~ p.309
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Effects of Ginsenoside Rb1 Loaded Films on Oral Wound Healing
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Lee Jeong-Hyun
Park Seung-Hwan
Mohammed Asiri Naif
Lee Myoung-Han
Kweon Dong-Keon
Chae Yong-Kwon
Lee Ko-Eun
Kim Mee-Seon
Lee Hyo-Seol
Choi Sung-Chul
Nam Ok-Hyung
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Abstract
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This study aimed to evaluate the effects of two ginsenoside Rb1 (G-Rb1) loaded films on oral wound healing. Two types of G-Rb1 films, G-Rb1 loaded carboxymethyl cellulose (GCMC) film and G-Rb1 loaded hyaluronic acid (GHA) film, were developed. A total of 36 Sprague-Dawley rats were divided into 3 groups: control, GCMC, and GHA. After wound formation on midpalate, the control group was left without treatment, whereas the experimental groups had films attached. The specimen was analyzed clinically and histologically after 7 and 21 days. For clinical analysis, the area of incompletely re-epithelialized wound was measured. For histological analysis, the distance between the margins of the wound (soft tissue gap) was measured and the percentage of the collagen-stained area on the specimen was calculated. In clinical and soft tissue gap analysis, the GCMC group presented improved healing compared to the GHA group and the control at day 7 (p < 0.05). And, both GCMC (9.74 ± 10.12%) and GHA groups (19.50 ± 14.47%) presented greater collagen-positive pixels compared to control (0.89 ± 1.60%) at day 7 (p < 0.05). However, there were no differences in these parameters among the groups on day 21. Therefore, G-Rb1 loaded films improved oral wound healing.
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KEYWORD
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Ginsenoside Rb1, Carboxymethyl cellulose, Hyaluronic acid, Wound healing, Reepithelialization
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